CircRNAs are a class of non-coding RNA that is emerging as key new members of the gene regulatory milieu, which are characterized by the presence of a covalent bond linking the 3′ and 5′ ends generated by backsplicing. CircRNAs are widely expressed in a tissue and developmental-stage specific pattern and a subset displays conservation across species. In accordance with an important role in the normal biology of the cell, perturbations of circRNA expression are now being reported in association with disease.
Functional circRNAs have been shown to act as sponges for micro RNAs and sequestering agents for RNA-binding protein as well as nuclear transcriptional regulators. In addition, several studies have shown the protein coding potential of the circRNA in human cells. Furthermore, the inherent stability of circRNAs due to the circularity and exonuclease resistance, and their expression in blood and exosome renders them potential candidates as disease biomarkers.
circBank is a comprehensive database of human circRNA which included more than 140,000 human annotated circRNA from different source. A novel nomenclature system based on the host gene name, start position and end position was applied for the naming of circRNA. In addition to the basic information of circRNA such as chromosome location and host gene, we added multiple new feature of circRNA in our database including predicted binding miRNA by two methods, circRNA protein coding potential, circRNA conservation, circRNA mutation and circRNA methylation. The database is publicly available and allows users to query the circRNA information based on different search criteria.
Glažar P, Papavasileiou P, & Rajewsky N. (2014). Circbase: a database for circular rnas. Rna-a Publication of the Rna Society, 20(11), 1666.
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